Isoroku Sekiguchi was born in Waialua, Hawaii on September 10, 1935. At the age of eight, he began to attend Sunday school at the Moiliili Mission, which was a branch of the Honolulu Holiness Church. His Sunday school teacher was Fusae (Miyoshi) Wakatani who led him to the Lord. On Easter Sunday 1948, Isoroku and his good friend, Kenji Yoshii, were baptized by Rev. Kichiro Fukuda. It was under the ministry of Arthur Tsuneishi that Isoroku dedicated his life to the Lord’s service.

In the ensuing years, Sekiguchi graduated from McKinley High School in Honolulu, El Camino College in California, and California State University, Los Angeles, where he obtained a degree in sociology. He married Irene Yukiko Yamagishi in 1961. After graduating from college, Sekiguchi managed a shoe store in Hawaii for two years and played an active role as a layman in the Honolulu Christian Church. Then he continued his studies for the ministry and graduated from the American Baptist Seminary of the West in Covina, California.

Sekiguchi served as an English-speaking pastor of the OMS Holiness Conference for twenty-five years, beginning as a student pastor m the West Los Angeles Holiness Church. He was assigned to the Sunnyvale Holiness Church in 1966, which merged with the Campbell Holiness Church in 1969 to become the Santa Clara Valley Japanese Christian Church. He then served the San Fernando Valley Holiness Church from 1972 to 1976. It was during this pastorate that a daughter, Carole Kikue, was born to Isoroku and Irene Sekiguchi. Unfortunately, after two years, she passed away.

From 1976 to 1984, Sekiguchi was the first pastor of the new work at the Pearl City Highlands Holiness Church. While ministering there, the Sekiguchis adopted a daughter, Janet Aiko. Isoroku’s last pastorate was the San Diego Japanese Christian Church where he ministered for three years.

In early 1987, Sekiguchi became very ill with a high fever of an unknown origin. Thus on March 26, 1987, he passed away of respiratory failure. “Iso,” as he was affectionately known, perceived the pastorate as a “servant ministry” and led each congregation with love and compassion. With his passing, the Holiness Conference lost one of its more promising young pastors.